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20+ Years of Evidence-Based Digital Health Innovation

The ALIVE Platform:
Proven Automated Behavior Change

From pioneering CD-ROM interventions to cloud-based applications, we've been developing and testing digital health solutions for over two decades. Fully customizable for diabetes prevention, workplace wellness, and other health behavior interventions.

The Challenge

Healthcare systems spend $327 billion annually on diabetes alone. Traditional health coaching programs cost $50,000+ per coach yearly, limiting reach to a fraction of the 88 million Americans who are prediabetic. With healthcare budgets strained, scalable automated solutions are essential.

Unlike traditional programs costing $1,000+ per participant, ALIVE delivers proven results at scale for under $100 per user.

20+ Year Track Record

A proven evolution of evidence-based interventions

2000: Little by Little CD-ROM → 2004: WIN Web Platform → 2009: ALIVE Workplace RCT → 2015: ALIVE-PD Diabetes Prevention

How the ALIVE Platform Works

Fully automated intervention requiring no human coaches

1

Baseline Assessment

Participants complete validated questionnaires. Algorithm analyzes diet, activity, and readiness for change.

2

Personalized Goals

Algorithm generates weekly small-step goals. Goals gradually increase, building sustainable habits.

3

Multi-Channel Delivery

Weekly emails, reminders, optional app, and automated phone coaching. Participants choose channels.

4

Progress Tracking

Log achievements, weight, and activity. Visual graphs show progress and reinforce positive changes.

5

Gamification

Points, team challenges, and achievement badges. Social features support engagement and motivation.

6

Adaptive Algorithms

System adjusts based on progress patterns. Non-responders receive different messaging strategies.

Featured Implementation

ALIVE-PD: Diabetes Prevention Success

Palo Alto Medical Foundation Research Institute, 339 participants

339
Participants
79%
Lost Weight
47%
Risk Factors Reduced
$389
Annual Savings

Primary Outcomes at 6 Months (p<0.001)

72%
Prediabetic by A1c
Returned to Normal
-7.4 mg/dL
Fasting Glucose
Reduction
-3.26 kg
Mean Weight Loss
(4% body weight)

HbA1c reduced by 0.26% overall (ITT analysis)
0.32% reduction for those prediabetic by A1c at baseline
All outcomes significantly better than control group

35%
Achieved ≥5% weight loss
(vs 8% control)
40%
Achieved normal fasting glucose
(vs 18% control)
44%
Reduced BMI by ≥1 kg/m²
(vs 19% control)

The Science Behind ALIVE

Evidence-based design grounded in behavioral science

Behavioral Foundation

Social Cognitive Theory

Self-efficacy through graduated goals

Behavioral Economics

Making healthy choices rewarding

Goal-Setting Theory

SMART goals adapted weekly

Evidence-Based Design

Theory-Grounded

Health belief model integrated

Personalized Plans

Gradual progression by fitness

Behavioral Strategies

Self-monitoring & rewards

Proven Features

Automated Coaching

IVR calls with tailored messages

Team Challenges

Social support without facilitation

Health Education

Weekly prevention content

Customize ALIVE for Your Research

Flexible platform adapts to your study needs and population

Duration

12, 24, 36, or 52 weeks
Match your study timeline

Focus Area

Diet, activity, or combined
Target specific behaviors

Population

Tailor for specific groups
Age, culture, health status

Intensity

Weekly or bi-weekly
Adjust engagement frequency

Language

Multiple languages
Culturally appropriate

Branding

Co-brand with institution
Seamless integration

Peer-Reviewed Evidence

Two decades of published research demonstrating platform effectiveness

Combined Impact

1,500+ participants studied • 4 major RCTs • ~1,000 citations • 20+ years of continuous research and development

A Randomized Trial of the Little by Little CD-ROM: Demonstrated Effectiveness in Increasing Fruit and Vegetable Intake in a Low-income Population
CD-ROM intervention • Foundation for digital health approach
Prev Chronic Dis 2004
Demonstration of an E-mailed Worksite Nutrition Intervention Program
Web-based nutrition intervention • Early platform success
Prev Chronic Dis 2004
Development of Alive! (A Lifestyle Intervention Via Email), and its effect on health-related quality of life, presenteeism, and other behavioral outcomes: randomized controlled trial
Platform development • Initial validation
JMIR 2008
Improving Diet and Physical Activity with ALIVE: A Worksite Randomized Trial
787 participants • Significant behavior change
Am J Prev Med 2009
A Fully Automated Diabetes Prevention Program, Alive-PD: Program Design and Randomized Controlled Trial Protocol
Study design • Implementation framework
JMIR Res Protoc 2015
Diabetes prevention and weight loss with a fully automated behavioral intervention by email, web, and mobile phone: a randomized controlled trial among persons with prediabetes
72% A1c normalization • 3.26 kg weight loss
JMIR 2015
Improving diet, activity and wellness in adults at risk of diabetes: randomized controlled trial
Improved fruit, vegetable intake, and physical activity
Nutrition and Diabetes 2016

Ready to Learn More?

Contact us to discuss how ALIVE can work for your research or organization

Contact Us

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